Cognitive deficits in aging and therapeutic evaluation of encephalotropic substances.

@article{Engel1988CognitiveDI,
  title={Cognitive deficits in aging and therapeutic evaluation of encephalotropic substances.},
  author={Rolf R. Engel and W Satzger},
  journal={Pharmacopsychiatry},
  year={1988},
  volume={21 Suppl 1},
  pages={8-10}
}
Several aspects relevant for the evaluation of encephalotropic substances are presented. A) Memory improving pharmacological effects found in animal studies are often lacking in human studies. B) Global clinical measures of therapeutic success differenciate well between verum and placebo. In contrast to psychological tests, however, objectivity and reliability of global measures is low. C) Diagnosing dementia requires laboratory screening, psychiatric judgment and psychological testing… CONTINUE READING