Cognitive deficits in a mouse model of pre-manifest Parkinson's disease.

  title={Cognitive deficits in a mouse model of pre-manifest Parkinson's disease.},
  author={Iddo Magen and Sheila M. Fleming and Chunni Zhu and Eddie C M Garcia and Katherine M Cardiff and Diana C. Dinh and Krystal De La Rosa and Maria Sanchez and Eileen Ruth S Torres and Eliezer Masliah and James David Jentsch and M F Chesselet},
  journal={The European journal of neuroscience},
  volume={35 6},
Early cognitive deficits are increasingly recognized in patients with Parkinson's disease (PD), and represent an unmet need for the treatment of PD. These early deficits have been difficult to model in mice, and their mechanisms are poorly understood. α-Synuclein is linked to both familial and sporadic forms of PD, and is believed to accumulate in brains of patients with PD before cell loss. Mice expressing human wild-type α-synuclein under the Thy1 promoter (Thy1-aSyn mice) exhibit broad… CONTINUE READING
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