Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures.

@article{Goorden2007CognitiveDI,
  title={Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures.},
  author={Susanna M I Goorden and Geeske M van Woerden and Louise van der Weerd and Jeremy P. Cheadle and Ype Elgersma},
  journal={Annals of neurology},
  year={2007},
  volume={62 6},
  pages={648-55}
}
OBJECTIVE Tuberous sclerosis complex (TSC) is characterized by brain lesions, epilepsy, increased incidence of mental retardation and autism. The causal link between lesion load and epilepsy on cognitive disabilities has been debated, and these factors explain only part of the intelligence quotient variability. A Tsc2 rat model of the disease provided evidence that the TSC genes are directly involved in neuronal function. However, these lesion- and epilepsy-free animals did not show learning… CONTINUE READING
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