Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats.

@article{DIntino2005CognitiveDA,
  title={Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats.},
  author={G. D'Intino and M. Paradisi and M. Fern{\'a}ndez and A. Giuliani and L. Aloe and L. Giardino and L. Calz{\`a}},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 8},
  pages={
          3070-5
        }
}
Clinical symptoms in multiple sclerosis include cognitive dysfunction. Difficulties in learning and remembering new information represent the most common cognitive deficit and are associated with a general and progressive brain pathology. Possible pathogenetic mechanisms for neuronal damage such as neuroprotective strategies are under active investigation also in experimental allergic encephalomyelitis, the most widely used experimental model for multiple sclerosis. In this paper we demonstrate… Expand
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