Cognitive decline as a manifestation of mitochondrial disorders (mitochondrial dementia).

  title={Cognitive decline as a manifestation of mitochondrial disorders (mitochondrial dementia).},
  author={Josef Finsterer},
  journal={Journal of the neurological sciences},
  volume={272 1-2},
Mitochondrial disorders, in particular respiratory chain diseases (RCDs), present either as single organ problem or as multi-system disease. One of the most frequently affected organs in RCDs, in addition to the skeletal muscle, is the central nervous system (CNS). CNS manifestations of RCDs include epilepsy, stroke-like episodes, migraine-like headache, ataxia, spasticity, movement disorders, psychosis, demyelination, calcification, but also dementia. Cognitive impairment may be a feature of… CONTINUE READING


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