Cognitive control and the COMT Val¹⁵⁸Met polymorphism: genetic modulation of videogame training and transfer to task-switching efficiency.

@article{Colzato2014CognitiveCA,
  title={Cognitive control and the COMT Val¹⁵⁸Met polymorphism: genetic modulation of videogame training and transfer to task-switching efficiency.},
  author={Lorenza S. Colzato and Wery P. M. van den Wildenberg and Bernhard Hommel},
  journal={Psychological research},
  year={2014},
  volume={78 5},
  pages={670-8}
}
The study investigated whether successful transfer of game-based cognitive improvements to untrained tasks might be modulated by preexisting neuro-developmental factors, such as genetic variability related to the catechol-O-methyltransferase (COMT)-an enzyme responsible for the degradation of dopamine. The COMT Val(158)Met genotype may differentially affect cognitive stability and flexibility, and we hypothesized that Val/Val homozygous individuals (who possess low prefrontal dopamine levels… CONTINUE READING

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