Cognitive changes as a result of a single exposure to placebo

@article{Morton2010CognitiveCA,
  title={Cognitive changes as a result of a single exposure to placebo},
  author={Debbie L. Morton and C. Brown and A. Watson and W. El-Deredy and Anthony K. P. Jones},
  journal={Neuropsychologia},
  year={2010},
  volume={48},
  pages={1958-1964}
}
Placebo has been shown to be a powerful analgesic with corresponding reduction in the activation of the pain matrix in the brain. However, the response to placebo treatment is highly variable. It is unclear how anticipatory and pain-evoked potentials are affected by the treatment and how reproducible the response is. Laser stimulation was used to induce moderate pain in healthy volunteers. We induced placebo analgesia by conditioning subjects to expect pain reduction by applying a sham… Expand
Experimental Placebo Analgesia Changes Resting-State Alpha Oscillations
TLDR
It is shown that resting alpha activity is modified by placebo analgesia, and this alpha activity might have been generated in medial components of the pain network, including dorsal anterior cingulate cortex, medial prefrontal cortex, and left insula. Expand
Placebo analgesia: cognition or perception.
TLDR
This chapter discusses how altered sensory processing by descending pain modulation may play a part in placebo analgesia and how the loss of the brains prefrontal regions can make it impossible to have a placebo response. Expand
PLACEBO ANALGESIA 1 Placebo Analgesia
SUMMARY The expectation of pain relief can exert a powerful analgesic effect, even when pain is severe. Depending on the nature of experiences and instructions provided, a placebo analgesic effectExpand
Investigating dose-dependent effects of placebo analgesia: A psychophysiological approach
TLDR
The study provided clear evidence that PA can occur in a “dose”‐dependent manner, mediated by the levels of expectancy for pain relief, and predicted ordering of the 3 fingers in terms of both response sensitivity and average response magnitude. Expand
ANALGESIC EFFECTS OF EEG ALPHA-WAVE ENTRAINMENT ON ACUTE AND CHRONIC PAIN
Pharmacological treatments for pain show limited analgesic benefits when compared with placebo. Neuro-modulatory approaches, such as mindfulness meditation and neurofeedback training show moreExpand
Expectations and positive emotional feelings accompany reductions in ongoing and evoked neuropathic pain following placebo interventions
TLDR
This first study to demonstrate placebo effects in ongoing neuropathic pain provides further evidence for placebo‐induced reduction in hyperalgesia and suggests that patients’ expectations coexist with emotional feelings about treatments. Expand
Mind really does matter The Neurobiology of Placebo-induced Anxiety Relief in Social Anxiety Disorder
The placebo effect, a beneficial effect attributable to a treatment containing no specific properties for the condition being treated, has been demonstrated in a variety of medical conditions. ThisExpand
Negative expectations interfere with the analgesic effect of safety cues on pain perception by priming the cortical representation of pain in the midcingulate cortex
TLDR
Investigation of the disruptive influence of threatening contexts on positive expectancy effects while 41 healthy volunteers experienced laser-induced heat pain suggests that threatening contexts disrupt the effect of pain relief cues via an aversive priming mechanism that enhances neural responses in the early stages of sensory processing. Expand
How does EEG Contribute to Our Understanding of the Placebo Response?: Insights from the Perspective of Bayesian Inference
TLDR
This chapter reviews the contribution that EEG studies have made to the understanding of anticipation of pain, and the role anticipation may have in priming pain perception and determining placebo analgesic responses. Expand
Placebo analgesia and beyond: a melting pot of concepts and ideas for neuroscience
TLDR
Recent evidence confirms and extends previous findings on the key role of prefrontal regions in the placebo response, and represents an excellent tool for neuroscience in the experimental setting. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 37 REFERENCES
Reproducibility of placebo analgesia: Effect of dispositional optimism
TLDR
It is suggested that repeated placebo responders are high in dispositional optimism and having a placebo response in the first session causes a drop in state anxiety at the beginning of the repeat session. Expand
Conditioned placebo responses.
TLDR
It is suggested that placebo responses are conditionable in the laboratory in both a positive and negative direction. Expand
Placebo effects in laser-evoked pain potentials
TLDR
The results suggest that placebo treatment affects early nociceptive processing, but that another component of placebo effects in reported pain occurs later, either in evaluation of pain or cognitive judgments about pain reports. Expand
Learning potentiates neurophysiological and behavioral placebo analgesic responses
TLDR
Findings indicate that prior positive experience plays a key role in maximizing both behavioral and neurophysiological placebo responses, emphasizing that the placebo effect is a learning phenomenon which affects the early central nociceptive processing. Expand
An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm
TLDR
The results show that although conditioning may be sufficient for placebo analgesia, it is likely to be mediated by expectancy and magnitudes of placebo effect are dependent on multiple factors, including conditioning, expectancy, and whether analgesia is assessed concurrently or retrospectively. Expand
Placebo analgesia is not due to compliance or habituation: EEG and behavioural evidence
TLDR
The results indicate that the reduction in pain during experimental placebo response is unlikely to be due to sensory habituation or compliance with the experimental instructions. Expand
Placebo conditioning and placebo analgesia modulate a common brain network during pain anticipation and perception
TLDR
The results suggest that the main effect of placebo arises from the reduction of anticipation of pain during placebo conditioning that is subsequently maintained during placebo analgesia. Expand
Response expectancies in placebo analgesia and their clinical relevance
TLDR
The results indicate that different verbal instructions about certain and uncertain expectations of analgesia produce different placebo analgesic effects, which in turn trigger a dramatic change of behaviour leading to a significant reduction of opioid intake. Expand
Categories of placebo response in the absence of site-specific expectation of analgesia
TLDR
Non‐site‐specific placebo analgesia by conditioning subjects to expect the anaesthetic cream on one arm, without specifying if they will definitely receive the cream, is investigated, facilitated by the absence of a site‐specific focus for the treatment. Expand
Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses.
TLDR
Placebo and nocebo effects are associated with opposite responses of DA and endogenous opioid neurotransmission in a distributed network of regions and form part of the circuit typically implicated in reward responses and motivated behavior. Expand
...
1
2
3
4
...