Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: A randomized controlled trial.

  title={Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: A randomized controlled trial.},
  author={David H. Barlow and Jack M. Gorman and M Katherine Shear and Scott W. Woods},
  volume={283 19},
CONTEXT Panic disorder (PD) may be treated with drugs, psychosocial intervention, or both, but the relative and combined efficacies have not been evaluated in an unbiased fashion. OBJECTIVE To evaluate whether drug and psychosocial therapies for PD are each more effective than placebo, whether one treatment is more effective than the other, and whether combined therapy is more effective than either therapy alone. DESIGN AND SETTING Randomized, double-blind, placebo-controlled clinical trial… 

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