Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain.

@article{Brzzka2010CognitiveAS,
  title={Cognitive and sensorimotor gating impairments in transgenic mice overexpressing the schizophrenia susceptibility gene Tcf4 in the brain.},
  author={Magdalena M. Brz{\'o}zka and Konstantin Radyushkin and Sven P. Wichert and Hannelore Ehrenreich and Moritz J Rossner},
  journal={Biological psychiatry},
  year={2010},
  volume={68 1},
  pages={33-40}
}
BACKGROUND The combined analysis of several large genome-wide association studies identified the basic helix-loop-helix (bHLH) transcription factor TCF4 as one of the most significant schizophrenia susceptibility genes. Its function in the adult brain, however, is not known. TCF4 belongs to the E-protein subfamily known to be involved in neurodevelopment. The messenger RNA expression of Tcf4 is sustained in the adult mouse brain, suggesting a function in the adult nervous system. Tcf4 null… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

Similar Papers

Loading similar papers…