Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice.

Abstract

Peripheral immune stimulation as well as certain types of psychological stress increases brain levels of inflammatory cytokines such as interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor alpha (TNFalpha). We have demonstrated that aged mice show greater increases in central inflammatory cytokines, as well as greater cognitive deficits, compared to… (More)
DOI: 10.1016/j.psyneuen.2008.02.013

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