Cognitive and histological disturbances after chlorpyrifos exposure and chronic Aβ(1-42) infusions in Wistar rats.

@article{RuizMuoz2011CognitiveAH,
  title={Cognitive and histological disturbances after chlorpyrifos exposure and chronic Aβ(1-42) infusions in Wistar rats.},
  author={Ana del Mar Ruiz-Mu{\~n}oz and Francisco A Nieto-Esc{\'a}mez and Susana Aznar and Maria Teresa Colomina and Fernando S{\'a}nchez-Santed},
  journal={Neurotoxicology},
  year={2011},
  volume={32 6},
  pages={836-44}
}
Exposure to pesticides has been linked to an increased vulnerability to neurodegenerative diseases. In order to study whether the exposure to the organophosphate chlorpyrifos renders the brain prone to amyloid-beta peptide deposition and accelerates its neuropathological and behavioural effects, Wistar rats were injected a single subcutaneous dose of chlorpyrifos (250 mg/kg) and subsequently infused with Aβ(1-42) peptide (i.c.v.) for 15 days. No effects of either treatment were noted in the… CONTINUE READING

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