Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer’s disease mice

@inproceedings{Lacoste2013CognitiveAC,
  title={Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer’s disease mice},
  author={Baptiste Lacoste and Xin-Kang Tong and Karim Lahjouji and R{\'e}jean Couture and Edith Hamel},
  booktitle={Journal of Neuroinflammation},
  year={2013}
}
Recent evidence suggests that the inducible kinin B1 receptor (B1R) contributes to pathogenic neuroinflammation induced by amyloid-beta (Aβ) peptide. The present study aims at identifying the cellular distribution and potentially detrimental role of B1R on cognitive and cerebrovascular functions in a mouse model of Alzheimer’s disease (AD). Transgenic mice overexpressing a mutated form of the human amyloid precursor protein (APPSwe,Ind, line J20) were treated with a selective and brain… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 77 references

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2000
View 4 Excerpts
Highly Influenced

A vascular connection to Alzheimer's disease.

Microcirculation • 2001
View 4 Excerpts
Highly Influenced

Age-dependent rescue by simvastatin of Alzheimer's disease cerebrovascular and memory deficits.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2012
View 7 Excerpts

Similar Papers

Loading similar papers…