Cognitive and behavioural impairment in amyotrophic lateral sclerosis

@article{Pender2020CognitiveAB,
  title={Cognitive and behavioural impairment in amyotrophic lateral sclerosis},
  author={Niall Pender and Marta Pinto-Grau and Orla Hardiman},
  journal={Current Opinion in Neurology},
  year={2020},
  volume={33},
  pages={649 - 654}
}
Purpose of review The current review provides an up to date overview of the nature and progression of the cognitive and behavioural impairment in amyotrophic lateral sclerosis (ALS). Understanding these symptoms has implications for the management of the disease and the design of clinical trials, in addition to the support of patient and caregiver regarding mental capacity and end of life decision-making. Recent findings Cognitive and behavioural change in ALS are best characterized as the… 
Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis
TLDR
It is shown that amyotrophic lateral sclerosis patients can be subgrouped into four phenotypes with distinct neurophysiological profiles, characterized by varying degrees of disruption in the somatomotor, frontotemporal, neural activity and frontoparietal networks, which reliably correlate with distinct clinical profiles and different disease trajectories.
Dysgraphic features in motor neuron disease: a review
TLDR
Evidence of writing impairment in MND patients is reviewed and the evaluation of writing abilities via writing-to-dictation/narrative writing tasks may be useful when assessing cognition/language in both neuropsychological-impaired and -unimpaires MND Patients - especially when severe dysarthria/anarthria is present and prevents clinicians from assessing oral language.
Multimodal assessment of autonomic dysfunction in amyotrophic lateral sclerosis
TLDR
The role of the autonomic nervous system in ALS is investigated using a multimodal approach to find out if non‐motor symptoms such as cognitive and behavioural deficits are frequent and underestimated in current diagnostic pathways.
Measuring social cognition in frontotemporal lobar degeneration: a clinical approach
TLDR
A clinical framework for the evaluation of social cognition is outlined and its role in the assessment of patients affected by a range of FTLD conditions is discussed.
Social cognition in the FTLD spectrum: evidence from MRI
TLDR
The current understanding of social cognition impairments in different FTLD conditions with respect to MRI is described.
Pain, disease severity and associations with individual quality of life in patients with motor neuron diseases
TLDR
Pain prevalence was high and the results pointed to that some participants experienced high pain severity, which indicate that pain assessments and pain treatments tailored to the specific needs of the MND population should be developed and scientifically evaluated.
ALS incidence and population aging in Northern Italy
TLDR
The increased incidence of ALS with time is real and can be largely interpreted as a reflection of the advancing age of the general population.
Dysgraphic features in motor neuron disease: a review
TLDR
This work has shown that MND patients can show oral language deficits mimicking those of frontotemporal degeneration (FTD), and dysgraphic features have also been reported within the disease.
...
...

References

SHOWING 1-10 OF 60 REFERENCES
Cognitive impairment in amyotrophic lateral sclerosis
Decline of cognitive and behavioral functions in amyotrophic lateral sclerosis: a longitudinal study
TLDR
It is found that those who changed their cognitive status presented a lower ALSFRS-r score at t1 and a shorter survival time compared to those who did not change, regardless of the type of cognitive impairment.
Behaviour in amyotrophic lateral sclerosis
TLDR
Behavioural changes of the type seen in FTD may be present even in a small consecutive cohort of ALS patients, as seen in a semi‐structured behavioural interview administered to carers of 16 consecutive patients attending a motor neuron disease clinic.
The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study
TLDR
Cognitive impairment, predominantly but not exclusively in the form executive dysfunction, is present in more than 40% of ALS patients who have no evidence of dementia, and its manifestations may be more heterogeneous than previously recognised.
Measurement of Social Cognition in Amyotrophic Lateral Sclerosis: A Population Based Study
TLDR
The Reading the Mind in the Eyes Test is a reliable measure of social cognitive processes in ALS using population-specific normative data, and has excellent psychometric properties when discriminating between ALS patients who are cognitively intact, and those who have executive impairment.
Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria
TLDR
These revised consensus criteria expand upon those of 2009 and embrace the concept of the frontotemporal spectrum disorder of ALS (ALS-FTSD), which is a re-conceptualisation that neuropsychological deficits in ALS fall along a spectrum.
Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy
TLDR
The lower educational attainment in patients with ALS-FTD indicated a possible role of cognitive reserve in ALS-related cognitive impairment, in keeping with a previous Irish study, despite the largely different genetic background of the two populations.
Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis
  • M. Strong, G. Grace, D. Figlewicz
  • Psychology, Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2009
TLDR
Recommendations arising from an international research workshop on frontotemporal dementia (FTD) and ALS address the requirement for a concise clinical diagnosis of the underlying motor neuron disease, defining the cognitive and behavioural dysfunction, and identifying the presence of disease modifiers.
...
...