Cognitive and behavioural impairment in amyotrophic lateral sclerosis

@article{Pender2020CognitiveAB,
  title={Cognitive and behavioural impairment in amyotrophic lateral sclerosis},
  author={Niall Pender and Marta Pinto-Grau and Orla Hardiman},
  journal={Current Opinion in Neurology},
  year={2020},
  volume={33},
  pages={649 - 654}
}
Purpose of review The current review provides an up to date overview of the nature and progression of the cognitive and behavioural impairment in amyotrophic lateral sclerosis (ALS). Understanding these symptoms has implications for the management of the disease and the design of clinical trials, in addition to the support of patient and caregiver regarding mental capacity and end of life decision-making. Recent findings Cognitive and behavioural change in ALS are best characterized as the… 
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Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis
TLDR
It is shown that amyotrophic lateral sclerosis patients can be subgrouped into four phenotypes with distinct neurophysiological profiles, characterized by varying degrees of disruption in the somatomotor, frontotemporal, neural activity and frontoparietal networks, which reliably correlate with distinct clinical profiles and different disease trajectories.
Dysgraphic features in motor neuron disease: a review
TLDR
Evidence of writing impairment in MND patients is reviewed and the evaluation of writing abilities via writing-to-dictation/narrative writing tasks may be useful when assessing cognition/language in both neuropsychological-impaired and -unimpaires MND Patients - especially when severe dysarthria/anarthria is present and prevents clinicians from assessing oral language.
Multimodal assessment of autonomic dysfunction in amyotrophic lateral sclerosis
TLDR
The role of the autonomic nervous system in ALS is investigated using a multimodal approach to find out if non‐motor symptoms such as cognitive and behavioural deficits are frequent and underestimated in current diagnostic pathways.
Measuring social cognition in frontotemporal lobar degeneration: a clinical approach
TLDR
A clinical framework for the evaluation of social cognition is outlined and its role in the assessment of patients affected by a range of FTLD conditions is discussed.
Social cognition in the FTLD spectrum: evidence from MRI
TLDR
The current understanding of social cognition impairments in different FTLD conditions with respect to MRI is described.
Pain, disease severity and associations with individual quality of life in patients with motor neuron diseases
TLDR
Pain prevalence was high and the results pointed to that some participants experienced high pain severity, which indicate that pain assessments and pain treatments tailored to the specific needs of the MND population should be developed and scientifically evaluated.
Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis
Predictors of survival in patients with amyotrophic lateral sclerosis: A large meta-analysis
ALS incidence and population aging in Northern Italy
TLDR
The increased incidence of ALS with time is real and can be largely interpreted as a reflection of the advancing age of the general population.
Dysgraphic features in motor neuron disease: a review
TLDR
This work has shown that MND patients can show oral language deficits mimicking those of frontotemporal degeneration (FTD), and dysgraphic features have also been reported within the disease.
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