• Corpus ID: 11485823

Cognitive and Psychomotor Effects of Antidepressants with Emphasis on Selective Serotonin Reuptake Inhibitors and the Depressed Elderly Patient

@inproceedings{Lane2000CognitiveAP,
  title={Cognitive and Psychomotor Effects of Antidepressants with Emphasis on Selective Serotonin Reuptake Inhibitors and the Depressed Elderly Patient},
  author={Roger M. Lane},
  year={2000}
}
  • R. Lane
  • Published 2000
  • Psychology, Biology
Cognitive and psychomotor impairment are important considerations in the treatment of depression in the elderly due to both the underlying slowing of cognitive and psychomotor processes as a normal function of aging and the superimposed deficits associated with the disease itself. Only the latter are reversible with effective antidepressant therapy. Yet certain antidepressant drugs possess sedating and otherwise impairing side effects that can further degrade the patients’ functional abilities… 

Figures and Tables from this paper

Effect of Selective Serotonin Reuptake Inhibitors on Psychomotor Function in Patients of Depression: A Comparative Study of Sertraline and Fluoxetine
TLDR
Findings of this study support the use of sertraline which had shown less impairment of psychomotor function in patients of depression as compared to fluoxetine, in special subgroups of population who operate machinery, drive vehicle or require alertness for the work.
Psychomotor Changes in Major Depressive Disorder during Sertraline Treatment
TLDR
Evidence pointing to potential beneficial effects of sertraline after a 6-week treatment period in the lower-order cognitive and motor components involved in the graphic motor performance of depressed patients is found.
An analysis of the effects of three commonly prescribed antidepressant agents on memory function
TLDR
Although all the three drugs were equally effective with regard to the remission of depressive symptoms, fluoxetine and citalopram recipients had significantly greater improvements in memory performance than imipramine recipients.
Does antidepressant therapy improve cognition in elderly depressed patients?
TLDR
Acute improvement in depression is associated with cognitive improvement as measured by the Shopping List Task and the Digit Symbol Substitution Test, which quantifies short-term and long-term memory storage and retrieval.
Antidepressants, serotonin and cognition : applied and fundamental studies in human volunteers
TLDR
It is concluded that serotonin is a potential target for pharmacological cognition enhancement, particularly for restoration of impaired cognitive performance due to serotonin dysfunction, and further differentiation of the role of serotonin in normal and disturbed cognition is required.
Effect of Donepezil on Cognitive Disorders Due to the Selective Serotonin Reuptake Inhibitors in the Patients with Major Depressive Disorder
TLDR
Cholinesterase inhibitors, such as donepezil, have had beneficial effects in improving cognitive impairment caused by selective serotonin reuptake inhibitor drugs compared to placebo.
Comparison of Effect of Antidepressants on Psychomotor Functions
TLDR
Sertraline significantly improves psychomotor function as compared to desvenlafaxine while fluoxetine impairs, and Hamilton rating score improved at the end of 3 months treatment asCompared to baseline.
Cognitive and psychomotor effects of paroxetine and sertraline on healthy elderly volunteers.
TLDR
Plasma sertraline levels were associated with mild and transient behavioral changes, as well as early termination in several subjects, and mixed-model random regression analyses revealed that Day 14 plasma paroxetine levels correlated negatively with delayed verbal recall and paired-associate learning scores.
Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitors
TLDR
The impairing and facilitating cognitive effects of paroxetine and sertraline, respectively, may be more pronounced in the elderly depressed patient and can be explained by subtle differences in pharmacological profiles of these SSRIs.
Spotlight on Sertraline in the Management of Major Depressive Disorder in Elderly Patients
TLDR
Sertraline is an effective and well tolerated antidepressant for the treatment of major depressive disorder in patients aged ≥60 years because of the drug’s comparatively low potential for drug interactions, which is of importance in patient groups such as the elderly who are likely to receive more than one drug regimen.
...
...

References

SHOWING 1-10 OF 339 REFERENCES
Avoiding and Managing Anticholinergic Effects of Antidepressants
TLDR
It is argued that for this reason, prescription of the classical tricyclic antidepressants should be avoided in elderly depressed patients and the second generation, or atypical antidepressants, and the newer selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) are considered to be useful alternatives in elderly patients.
Paroxetine in the elderly depressed patient: randomized comparison with fluoxetine of efficacy, cognitive and behavioural effects
TLDR
Both treatments produced improvements in all measures of cognitive and behavioural function, but paroxetine was significantly superior to fluoxetines from Week 3, indicating a possible early effect.
Sedative antidepressants impair visual detection mechanisms in humans
TLDR
Investigation of whether these drugs impair visual selective attention by employing the 'odd-ball' task found preliminary evidence that both drugs delayed responses to central targets compared with placebo on the divided attention trials and response accuracy in detecting peripheral targets was greater under placebo compared with fluvoxamine and dothiepin.
A double blind comparison of the effects of fluoxetine and amitriptyline on cognitive function in elderly depressed patients
TLDR
The results show that FLU and AMI were equally effective in relieving depression, however, the psychometric test battery showed that, compared to FLU, AMI, as expected, produced impairments in cognitive function and psychomotor performance.
Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia.
TLDR
Fluoxetine appears to be significantly less effective than nortriptyline for treating hospitalized elderly patients with unipolar major affective disorder, especially those with the melancholic subtype and concurrent cardiovascular disease.
Comparative Tolerability Profiles of the Newer versus Older Antidepressants
TLDR
The availability of new-generation antidepressants increases the likelihood of clinical response with a reduction in unwanted toxicity, and Monoamine oxidase (MAO) inhibitors have also been refined; reversible inhibitors of MAO-type A afford protection against the usually feared hypertensive reaction to indirect sympathomimetic substances.
[Effects of antidepressants on cognitive functions. Review of the literature].
TLDR
It is concluded that the Critical Flicker Fusion Test (CFFT) is one of the most drug-sensitive tests and permits a categorization in: sedative antidepressants that in single administration lower CFFT; compounds with no effect on CffT and no deleterious cognitive effect; and finally substances that raise C FFT and may have psychostimulating properties.
Predictors of an acute antidepressant response to fluoxetine and sertraline.
TLDR
Analysis of a randomized, double-blind, 6-week study comparing sertraline with fluoxetine in 286 outpatients with major depression showed that significant differences existed in favour of sertRALine in patients with low anxiety in the melancholia and severe depression subgroups, indicating that these characteristics predicted a superior response to 6 weeks of treatment with sERTraline relative to fluoxettine.
A comparison of the effect of fluoxetine and trazodone on the cognitive functioning of depressed outpatients.
...
...