Cognitive activity and the cognitive morbidity of Alzheimer disease.

  title={Cognitive activity and the cognitive morbidity of Alzheimer disease.},
  author={Robert Smith Wilson and Lisa L. Barnes and Neelum Thanik Aggarwal and Patricia A. Boyle and Liesi E Hebert and Carlos F. Mendes de Leon and Denis A. Evans},
  volume={75 11},
OBJECTIVE To test the hypothesis that frequent cognitive activity predicts slower cognitive decline before dementia onset in Alzheimer disease (AD) and faster decline thereafter. METHODS As part of a longitudinal cohort study, older residents of a geographically defined population were assessed at 3-year intervals with brief cognitive performance tests from which a composite measure of global cognition was derived. After each wave of testing, a subset was sampled for clinical evaluation. The… CONTINUE READING
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