Cognitive Inflexibility and Pre-frontal Dysfunction in Schizophrenia and Mania

  title={Cognitive Inflexibility and Pre-frontal Dysfunction in Schizophrenia and Mania},
  author={Rodney D. Morice},
  journal={British Journal of Psychiatry},
  pages={50 - 54}
  • R. Morice
  • Published 1 July 1990
  • Psychology, Medicine
  • British Journal of Psychiatry
The ability to shift cognitive set, which is probably subserved, at least in part, by the pre-frontal cortex, was determined for schizophrenic, bipolar (manic) and control subjects, using the Wisconsin Card Sorting Test (WCST). The schizophrenic and manic subjects both demonstrated poor performance on the WCST, suggesting that cognitive inflexibility and/or pre-frontal dysfunction, is not specific to schizophrenia (although laterality differences could exist). Moderate levels of poor… 
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