Cognitive Inflexibility and Pre-frontal Dysfunction in Schizophrenia and Mania

@article{Morice1990CognitiveIA,
  title={Cognitive Inflexibility and Pre-frontal Dysfunction in Schizophrenia and Mania},
  author={Rodney D. Morice},
  journal={British Journal of Psychiatry},
  year={1990},
  volume={157},
  pages={50 - 54}
}
  • R. Morice
  • Published 1 July 1990
  • Psychology, Medicine
  • British Journal of Psychiatry
The ability to shift cognitive set, which is probably subserved, at least in part, by the pre-frontal cortex, was determined for schizophrenic, bipolar (manic) and control subjects, using the Wisconsin Card Sorting Test (WCST). The schizophrenic and manic subjects both demonstrated poor performance on the WCST, suggesting that cognitive inflexibility and/or pre-frontal dysfunction, is not specific to schizophrenia (although laterality differences could exist). Moderate levels of poor… 
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References

SHOWING 1-10 OF 35 REFERENCES
Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test.
TLDR
The data suggest that prefrontal-type cognitive deficits in schizophrenia may be more profound than is generally appreciated.
Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal, or parietal function in neurological patients.
TLDR
The performances of schizophrenic patients and normal control subjects were compared on an extensive battery of psychological tests and imply that schizophrenia results, at least in part, from a bilateral dysfunction of the frontal and temporal lobes.
On frontal lobe functions: psychiatric patient controls.
  • H. P. Malmo
  • Psychology, Medicine
    Cortex; a journal devoted to the study of the nervous system and behavior
  • 1974
Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism.
TLDR
A new cohort of 16 medication-free patients underwent a series of xenon 133 inhalation rCBF studies and showed that behavior-specific hypofunction of DLPFC in schizophrenia is reproducible, and they implicate a monoaminergic mechanism.
Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention, and mental effort.
TLDR
The data suggest that DLPFC dysfunction in schizophrenia is independent of medication status and not determined simply by state factors such as attention, mental effort, or severity of psychotic symptoms.
The Effects of Antipsychotic Medication on the Linguistic Ability of Schizophrenics
TLDR
It is suggested that drug treatment can enhance patients' capacity to utilize verbally oriented psychotherapy and show an increase in the complexity and coherence of their speech and a decrease in pathological utterances.
Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence.
TLDR
Autonomic arousal measures, the pattern of WCS errors, and results of complementary studies suggest that the DLPFC finding is linked to regionally specific cognitive function and is not a nonspecific epiphenomenon.
Implications of normal brain development for the pathogenesis of schizophrenia.
  • D. Weinberger
  • Psychology, Medicine
    Archives of general psychiatry
  • 1987
TLDR
The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
A Modified Card Sorting Test Sensitive to Frontal Lobe Defects
Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes
Sorting tasks, requiring the subject to respond selectively, first to one aspect of a situation and then to another, have traditionally been regarded as sensitive indicators of brain injury, but
...
...