Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

@inproceedings{Vials2015CognitiveII,
  title={Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors},
  author={Xavier Vi{\~n}als and E. {\'A}lvarez Moreno and Laurence Lanfumey and Arnau Cordom{\'i} and A Bardina Pastor and Rafael de la Torre and Paola Gasperini and Gemma Navarro and Lesley Ann Howell and Leonardo Pardo and Carmen Lluis and Enric I. Canela and Peter J. McCormick and Rafael Maldonado and Patricia Robledo and Eric J Nestler},
  booktitle={PLoS biology},
  year={2015}
}
Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of cannabinoids as therapeutic agents. For this reason, there is a tremendous medical interest in harnessing the beneficial effects of THC. Behavioral studies carried out in mice lacking 5-HT2A receptors (5-HT2AR) revealed a remarkable 5-HT2AR-dependent dissociation in the beneficial… CONTINUE READING
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