Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed

  title={Cognitive Enhancing and Neuroprotective Effect of the Embryo of the Nelumbo nucifera Seed},
  author={Eun Sil Kim and Jin Bae Weon and Bo-Ra Yun and Jiwoo Lee and Min Rye Eom and Kyoung-Hee Oh and Choong Je Ma},
  booktitle={Evidence-based complementary and alternative medicine : eCAM},
The aim of the present study was to evaluate the effect of ENS on cognitive impairment induced by scopolamine and its potential neuroprotective effect against glutamate-induced cytotoxicity in HT22 cell and to investigate the underlying mechanisms. ENS (3, 10, 30, and 100 mg/kg), scopolamine (1 mg/kg), and donepezil (1 mg/kg) were administered to mice during a test period. Scopolamine impaired memory and learning in a water maze test and a passive avoidance test. The neuroprotective effect of… CONTINUE READING


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