Cognitive-Enhancing Effect of Aronia melanocarpa Extract against Memory Impairment Induced by Scopolamine in Mice

@article{Lee2016CognitiveEnhancingEO,
  title={Cognitive-Enhancing Effect of Aronia melanocarpa Extract against Memory Impairment Induced by Scopolamine in Mice},
  author={Hyeon Yong Lee and Jin Bae Weon and Youn Sik Jung and Nam Young Kim and Myong-Ki Kim and Choong Je Ma},
  journal={Evidence-based Complementary and Alternative Medicine : eCAM},
  year={2016},
  volume={2016}
}
  • H. Lee, J. Weon, +3 authors C. Ma
  • Published 2016
  • Chemistry, Medicine
  • Evidence-based Complementary and Alternative Medicine : eCAM
Aronia melanocarpa (A. melanocarpa) berries are a fruit with a marked antioxidant effect. The objective of this study was to confirm the effect of A. melanocarpa berries extract against scopolamine-induced memory impairment in mice using the Morris water maze and passive avoidance test. Moreover, we determined a possible mechanism of the cognitive-enhancing effect involving AChE activity and BDNF and p-CREB expression in the hippocampus of mice. A. melanocarpa berries extract attenuated the… Expand
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References

SHOWING 1-10 OF 29 REFERENCES
Effect of Aronia Melanocarpa Fruit Juice on Fearning and Memory in the Two-Way Active Avoidance Task in Rats
TLDR
The findings from the present study suggest that AMFJ applied subchronically improved learning and memory in young/healthy rats. Expand
Memory Effects Of Aronia Melanocarpa Fruit Juice In A Passive Avoidance Test In Rats
TLDR
It is suggested that Aronia melanocarpa fruit juice could improve memory in rats, probably due to the polyphenolic ingredients of the juice which have been shown to be involved in learning and memory processes. Expand
Scopolamine effects on memory retention in mice: a model of dementia?
TLDR
The overall results indicate that pretraining administration of scopolamine impairs learning and to some degree memory processing, in addition to some impairment of memory processing. Expand
Chronic scopolamine-injection-induced cognitive deficit on reward-directed instrumental learning in rat is associated with CREB signaling activity in the cerebral cortex and dorsal hippocampus
TLDR
The results suggest that scopolamine-induced cognitive deficits on RDIL are related to the distinguishing alteration of CREB signaling in the DH and CCx. Expand
Protective effect of Aronia melanocarpa polyphenols against cadmium-induced disorders in bone metabolism: a study in a rat model of lifetime human exposure to this heavy metal.
TLDR
It is suggested that consumption of Aronia melanocarpa polyphenols may play a role in prevention against female skeleton damage due to chronic exposure to Cd and that chokeberry represents the good natural plant candidate for further investigations of its prophylactic use under environmental exposure to this heavy metal. Expand
Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide
TLDR
The data obtained show that the enhancement of AChE activity induced by Abeta(25-35) is mediated by oxidative stress, and that vitamin E and NOS inhibitors can have an important role in the maintenance of acetylcholine synaptic levels, thus preventing or improving cognitive and memory functions of AD patients. Expand
The Involvement of a Polyphenol-Rich Extract of Black Chokeberry in Oxidative Stress on Experimental Arterial Hypertension
TLDR
Ethanolic extract of black chokeberry fruits not only has a potential value as a prophylactic agent but also may function as a nutritional supplement in the management of arterial hypertension. Expand
Acetylcholine: a neurotransmitter for learning and memory?
  • A. Blokland
  • Medicine, Psychology
  • Brain Research Reviews
  • 1995
TLDR
This review aims to assess the data of studies in which the role of acetylcholine (ACh) in cognitive functions was investigated, and finds that on basis of the available data, ACh seems to be more specifically involved in attentional processes than in learning and memory processes. Expand
Current knowledge of Aronia melanocarpa as a medicinal plant.
TLDR
Investigations have demonstrated a remarkable hepatoprotective, a very good gastroprotective and a pronounced anti-inflammatory effect of Aronia melanocarpa fruit juice in rats as well as a bacteriostatic activity in vitro against Staphylococcus aureus and Escherichia coli and an antiviral activity against type A influenza virus. Expand
Aronia melanocarpa phenolics and their antioxidant activity
The purpose of the present study was to evaluate small and high molecular phenolics (tannins) and antioxidant activity of Aronia melanocarpa berries, juice and pomace in order to find new potentialExpand
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