Cognitive Enhancement Therapy for Alzheimer’s Disease

@article{Parnetti2012CognitiveET,
  title={Cognitive Enhancement Therapy for Alzheimer’s Disease},
  author={Lucilla Parnetti and Umberto Senin and Patrizia Mecocci},
  journal={Drugs},
  year={2012},
  volume={53},
  pages={752-768}
}
SummaryAlthough at present there is no definitive treatment or cure for Alzheimer’s disease, different pharmacological strategies are being actively investigated. At present, cholinergic therapy and nootropics and some neuronotrophic agents represent the available approaches to symptomatic treatment of Alzheimer’s disease. The use of cholinesterase inhibitors (ChEI) constitutes the best cholinergic approach to increase acetylcholine levels. Available data suggest that about 15 to 40% of… Expand
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References

SHOWING 1-10 OF 138 REFERENCES
Brain selective inhibition of acetylcholinesterase: a novel approach to therapy for Alzheimer's disease.
TLDR
The results presented with SDZ ENA 713 indicate that the disadvantages of AChE inhibitors might be overcome by improving CNS selectivity and thereby decreasing the peripheral cholinergic effects and toxicity. Expand
Treatment of Alzheimer's disease: future directions
TLDR
Protective approaches, which depend on the development of more effective methods for predicting and diagnosing AD, include the administration of nerve growth factor and other neurotrophins and the use of pharmacologic or genetic interventions to limit amyloid deposition and the formation of neurofibrillary tangles. Expand
Alzheimer's disease and related disorders.
The cholinesterase inhibitors provide the first clearly effective treatments for the cognitive deficits of AD and appear to have a beneficial effect on activities of daily living function and… Expand
Mechanisms of cholinesterase inhibition in senile dementia of the alzheimer type: Clinical, pharmacological, and therapeutic aspects
Senile dementia of the Alzheimer type (SDAT) is a degenerative disease of the brain that affects up to 20% or more of individuals who live beyond 80 years of age. A deficiency of cholinergic function… Expand
A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group.
TLDR
Treatment with tacrine resulted in a statistically significant reduction in the decline of cognitive function, although this reduction was not large enough to be detected by the study physicians' global assessments of the patients. Expand
Alzheimer disease : therapeutic strategies
This volume provides reviews of advances in basic and clinical sciences that are relevant to understanding the aetiology, pathogenesis and diagnosis of Alzheimer's disease, with particular emphasis… Expand
Idebenone in senile dementia of Alzheimer type: a multicentre study.
TLDR
Tolerability to idebenone treatment was good and was associated with a statistically significant improvement of memory, attention and behaviour, and it is worthwhile noting that these cognitive and behavioral findings were observed after the first month of treatment with enhancement evident in the following period. Expand
Treatment of Alzheimer's disease with cholinergic drugs.
  • V. Kumar, M. Calache
  • Medicine
  • International journal of clinical pharmacology, therapy, and toxicology
  • 1991
TLDR
It is concluded that cholinergic drugs alone may not be the answer to treat Alzheimer disease patients and there seems to be a need to develop drug(s) which could affect several neurotransmitter or neuromodulator systems. Expand
Inflammatory mechanisms in Alzheimer's disease: implications for therapy.
TLDR
There is ample evidence supporting the hypothesis that inflammatory and immune mechanisms are involved in tissue destruction in Alzheimer's disease and clinical trials of anti-inflammatory/immunosuppressive drugs are necessary to determine whether alteration of these inflammatory mechanisms can slow the progression of Alzheimer's Disease. Expand
Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies
Partial table of contents: CLINICAL COURSE. Multidisciplinary Validation of Two Dementia Categories (N. Verma, et al.). NEUROPATHOLOGY: STRUCTURAL AND BIOCHEMICAL. Entorhinal Lesions in Dementia (H.… Expand
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5
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