Cognitive Dysfunction in Chronic Fatigue Syndrome: a Review of Recent Evidence

@article{Cvejic2016CognitiveDI,
  title={Cognitive Dysfunction in Chronic Fatigue Syndrome: a Review of Recent Evidence},
  author={Erin Cvejic and Rachael Cherie Birch and Ute Vollmer-Conna},
  journal={Current Rheumatology Reports},
  year={2016},
  volume={18},
  pages={1-10}
}
Cognitive difficulties represent a common and debilitating feature of the enigmatic chronic fatigue syndrome (CFS). These difficulties manifest as self-reported problems with attention, memory, and concentration and present objectively as slowed information processing speed particularly on complex tasks requiring sustained attention. The mechanisms underlying cognitive dysfunction remain to be established; however, alterations in autonomic nervous system activity and cerebral blood flow have… 
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References

SHOWING 1-10 OF 71 REFERENCES
Cognitive impairments associated with CFS and POTS
TLDR
Future research should continue to examine possible explanations for cognitive impairments in CFS and POTS, and ultimately use this information to try and reduce Cognitive impairments for these patients.
Cognitive dysfunction in fibromyalgia and chronic fatigue syndrome: New trends and future directions
  • J. Glass
  • Medicine
    Current rheumatology reports
  • 2006
TLDR
Objective cognitive testing demonstrates long-term and working memory impairments and cerebral abnormalities and a pattern of increased neural recruitment during cognitive tasks in fibromyalgia and chronic fatigue syndrome patients.
Neuropsychological deficits in chronic fatigue syndrome: artifact or reality?
TLDR
A comprehensive summary and discussion of the results from neuropsychological studies which have compared patients with chronic fatigue syndrome with controls or normative data are provided to provide both some clarity in the area and directions for future research.
Caught in the thickness of brain fog: exploring the cognitive symptoms of Chronic Fatigue Syndrome
  • A. Ocon
  • Medicine, Biology
    Front. Physiol.
  • 2013
Chronic Fatigue Syndrome (CFS) is defined as greater than 6 months of persistent fatigue that is experienced physically and cognitively. The cognitive symptoms are generally thought to be a mild
Psychosocial factors involved in memory and cognitive failures in people with myalgic encephalomyelitis/chronic fatigue syndrome
TLDR
It is suggested that fatigue and depression may be a result of the neurobiological effects of ME/CFS and in addition, that the neuro biological effects of the illness may give rise to both fatigue and cognitive deficits independently.
Cognitive functioning in chronic fatigue syndrome: a meta-analysis
TLDR
Evidence of cognitive deficits in persons with CFS was found primarily in the domains of attention, memory and reaction time, and was not apparent on tests of fine motor speed, vocabulary, reasoning and global functioning.
The Neuropsychiatric and Neuropsychological Features of Chronic Fatigue Syndrome: Revisiting the Enigma
TLDR
A comprehensive and updated review of the key neuropsychiatric and neuropsychological complaints associated with chronic fatigue syndrome is provided in an effort to understand the significance of cognitive impairment in CFS.
Neurocognitive functioning in chronic fatigue syndrome
TLDR
The current paper reviews studies that have examined the neurocognitive and/or psychological functioning of individuals with CFS and suggests changes in research design and instruments employed to study individuals withCFS are suggested.
Associations Between Cognitive Performance and Pain in Chronic Fatigue Syndrome: Comorbidity with Fibromyalgia Does Matter.
TLDR
The results underline disease heterogeneity in CFS by indicating that a measure of endogenous pain inhibition might be a significant predictor of cognitive functioning in C FS patients with FM, while self-reported pain appears more appropriate to predict cognitive functioningIn CFS patients without FM.
Neuropsychological Impairment in Female Patients with Chronic Fatigue Syndrome: A Preliminary Study
TLDR
Cognitive dysfunction in CFS could be explained by pathophysiological processes of the disease, and one implication of this would be the need to identify homogeneous subgroups of patients with CFS by taking into account common factors, which would help to identify more specific cognitive profiles, which could then serve to implement appropriate therapeutic measures accordingly.
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