Cognitive Deterioration and Associated Pathology Induced by Chronic Low-Level Aluminum Ingestion in a Translational Rat Model Provides an Explanation of Alzheimer's Disease, Tests for Susceptibility and Avenues for Treatment

@inproceedings{Walton2012CognitiveDA,
  title={Cognitive Deterioration and Associated Pathology Induced by Chronic Low-Level
Aluminum Ingestion in a Translational Rat Model Provides an Explanation of
Alzheimer's Disease, Tests for Susceptibility and Avenues for Treatment},
  author={Judie R. Walton},
  booktitle={International journal of Alzheimer's disease},
  year={2012}
}
A translational aging rat model for chronic aluminum (Al) neurotoxicity mimics human Al exposure by ingesting Al, throughout middle age and old age, in equivalent amounts to those ingested by Americans from their food, water, and Al additives. Most rats that consumed Al in an amount equivalent to the high end of the human total dietary Al range developed severe cognitive deterioration in old age. High-stage Al accumulation occurred in the entorhinal cortical cells of origin for the perforant… CONTINUE READING
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Evidence that total dietary aluminum ingestion is a major risk factor for Alzheimer’s disease

  • J. R. Walton
  • Current Inorganic Chemistry, vol. 2, pp. 19–39…
  • 2012
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