Cognitive Deficits in Machado–Joseph Disease Correlate with Hypoperfusion of Visual System Areas

@article{BragaNeto2012CognitiveDI,
  title={Cognitive Deficits in Machado–Joseph Disease Correlate with Hypoperfusion of Visual System Areas},
  author={Pedro Braga-Neto and L{\'i}via Almeida Dutra and J L Pedroso and Andre C Felicio and Helena Alessi and Ruth Ferreira Santos-Galdur{\'o}z and Paulo Henrique Ferreira Bertolucci and Mario Luiz Vieira Castiglioni and Rodrigo Affonseca Bressan and Griselda J. Garrido and O G P Barsottini and Andrea Parolin Jackowski},
  journal={The Cerebellum},
  year={2012},
  volume={11},
  pages={1037-1044}
}
Cognitive and olfactory impairments have previously been demonstrated in patients with spinocerebellar ataxia type 3 (SCA3), also known as Machado–Joseph disease (MJD)—SCA3/MJD. We investigated changes in regional cerebral blood flow (rCBF) using single-photon emission computed tomography (SPECT) imaging in a cohort of Brazilian patients with SCA3/MJD. The aim of the present study was to evaluate the correlation among rCBF, cognitive deficits, and olfactory dysfunction in SCA3/MJD. Twenty-nine… CONTINUE READING