Cognitive Deficits in Depression and Functional Specificity of Regional Brain Activity

@article{Levin2007CognitiveDI,
  title={Cognitive Deficits in Depression and Functional Specificity of Regional Brain Activity},
  author={Rebecca L. Levin and Wendy Heller and Aprajita Mohanty and John D. Herrington and Gregory A. Miller},
  journal={Cognitive Therapy and Research},
  year={2007},
  volume={31},
  pages={211-233}
}
The growing literature on cognitive deficits in depression is considered in light of regional brain activity as well as comorbid anxiety and life stressors. Cognitive impairments associated with depression are reviewed, with an emphasis on various aspects of executive function such as memory, attention, and problem-solving. These deficits are related to patterns of brain activity observed in prefrontal, anterior cingulate, and parietal cortices, as well as in subcortical regions. Evidence for… 
Cognitive Functioning in Major Depression – A Summary
TLDR
Depression is associated with cognitive impairment in the acute phase of illness, and some reports indicate that this impairment might be long lasting despite symptom reduction and recovery.
The Bewildered Brain: Asymmetric Brain Activity as a Source of Cognitive Impairment in Depression
Individuals with depression commonly complain about cognitive deficits such as memory loss and poor decision making ability (Lahr, Beblo, & Hartje, 2007). However, despite considerable research, no
Prefrontal cortical organization of executive function in depression and comorbid anxiety
Cognitive deficits are a prominent source of distress and functional impairment in both depression and anxiety, yet our understanding of these deficits and their mechanisms are limited. These
Executive function and attention in children and adolescents with depressive disorders: a systematic review
TLDR
While across different domains of EF some studies identified a deficit in the clinical group, the majority of studies failed to find deficits in response inhibition, attentional set shifting, selective attention, verbal working memory, and verbal fluency.
Relationships among cognition, emotion, and motivation: implications for intervention and neuroplasticity in psychopathology
TLDR
Evidence for cognitive biases and deficits in depression and anxiety are reviewed and the role of neuroplasticity in implementing change in cognitive, emotional, and motivational processes in psychopathology as a function of intervention is integrated.
Serotonergic Modulation of Cognition in Prefrontal Cortical Circuits in Major Depression
Abstract Cognitive processes are altered in depression patients, and their neuromodulation by serotonergic treatments may depend on the specific pathophysiology of the disease. Here, we addressed
Cognitive dysfunction in depression: lessons learned from animal models.
TLDR
This review will highlight studies with animal models that have helped in understanding the mechanisms involved in cognitive impairment associated with depression, as well as focus on effective treatments that assist in improving both depression and cognition.
Cortical organization of inhibition-related functions and modulation by psychopathology
TLDR
Results imply that specific combinations of anxiety and depression dimensions are associated with failure to implement top-down attentional control as reflected in inefficient recruitment of posterior DLPFC and increased activation in regions associated with threat (MTG and worry) and worry.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 207 REFERENCES
Impaired attention in depressive states: a non-specific deficit?
TLDR
The limited neuropsychological literature on impaired attention in depressive states is reviewed, with emphasis on areas where the findings of modern cognitive research might be applied in the future to design more sophisticated tests of attentional impairment.
Cognitive deficits in depression: Possible implications for functional neuropathology
TLDR
A focus on the interactions between motivation, affect and cognitive function may allow greater understanding of the interplay between key aspect of the dorsal and ventral aspects of the prefrontal cortex in depression.
Neuropsychological differentiation of depression and anxiety.
TLDR
A neuropsychological model of regional brain activity in emotion provides contrasting hypotheses for depression and anxiety, which received support in a comparison of individuals diagnosed with depression and community controls, and in a separate study of nonpatients administered a measure of perceptual asymmetry.
Prefrontal cortex activity differentiates processes affecting memory in depression
TLDR
Brain mechanisms accompanying the initiative deficit and negative bias processes affecting memory in depressed individuals were investigated and negative memory bias in depressed participants was inferred from their association between right prefrontal activity during the sad narrative and memory performance.
Executive and prefrontal dysfunction in unipolar depression: a review of neuropsychological and imaging evidence
TLDR
The evidence from combined imaging and neuropsychological studies supports the involvement of the ACC, but is less clear in the case of the DLPFC, and the limited number of such studies conducted to date means that conclusions must be tentative.
Biases of attention and memory in disorders of anxiety and depression
Abstract Theoretical frameworks and experimental paradigms derived from cognitive psychology provide a valuable approach to the investigation of cognitive aspects of disorders of anxiety and
The role of the cingulate gyrus in depression: From functional anatomy to neurochemistry
TLDR
It is concluded that neuroimaging techniques are starting to equip us to conceptualize functional changes in the limbic loop containing the anterior cingulate as the common denominator of change and therapy effects in depressive states.
Evidence for continuing neuropsychological impairments in depression.
BACKGROUND Neuropsychological deficits have been reported in patients with major depressive disorder (MDD) during an acute episode of MDD. Little is known whether these abnormalities persist when
Cognitive aspects of chronic depression.
TLDR
Chronic depressed individuals were generally more elevated on measures of cognitive variables than those with major depressive disorders even after controlling for mood state and personality disorder symptoms.
Hippocampal volume reduction in major depression.
TLDR
These findings are consistent with smaller left hippocampal volume in depression, and were significant after brain size, alcohol exposure, age, and education were controlled for.
...
1
2
3
4
5
...