Cognition in transmembrane domain <ce:italic>neuregulin 1</ce:italic> mutant mice

@article{Duffy2010CognitionIT,
  title={Cognition in transmembrane domain <ce:italic>neuregulin 1</ce:italic> mutant mice},
  author={Liesl Duffy and Emily Cappas and Donna Lai and Aur{\'e}lie A. Boucher and Tim Karl},
  journal={Neuroscience},
  year={2010},
  volume={170},
  pages={800-807}
}
Neuregulin 1 (NRG1), which has been implicated in the development of schizophrenia, is expressed widely throughout the brain and influences key neurodevelopmental processes such as myelination and neuronal migration. The heterozygous transmembrane domain Nrg1 mutant mouse (Nrg1 TM HET) exhibits a neurobehavioural phenotype relevant for schizophrenia research, characterized by the development of locomotor hyperactivity, social withdrawal, increased sensitivity to environmental manipulation, and… CONTINUE READING
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