Cognition following acute tryptophan depletion: difference between first-degree relatives of bipolar disorder patients and matched healthy control volunteers.

@article{Sobczak2002CognitionFA,
  title={Cognition following acute tryptophan depletion: difference between first-degree relatives of bipolar disorder patients and matched healthy control volunteers.},
  author={Sjacko Sobczak and Wim J. Riedel and Ilja Booij and Marije Aan Het Rot and Nicolaas E P Deutz and A Honig},
  journal={Psychological medicine},
  year={2002},
  volume={32 3},
  pages={503-15}
}
BACKGROUND Serotonergic circuits have been proposed to mediate cognitive processes, particularly learning and memory. Cognitive impairment is often seen in bipolar disorders in relation to a possible lowered serotonergic turnover. METHODS We investigated the effects of acute tryptophan depletion (ATD) on cognitive performance in healthy first-degree relatives of bipolar patients (FH) (N= 30) and matched controls (N= 15) in a placebo-controlled, double-blind cross-over design. Performance on… CONTINUE READING

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