Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS.

@article{Blokland1999CognitionenhancingPO,
  title={Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS.},
  author={Arjan A. J. Blokland and Wiel M. M. Honig and Fred Brouns and Jelle Jolles},
  journal={Nutrition},
  year={1999},
  volume={15 10},
  pages={
          778-83
        }
}
There are various clinical and non-clinical studies that have indicated that phosphatidylserine (PS) treatment can improve cognitive functions in humans and other animals. However, treatment with PS derived from bovine cortex is not desirable because of possible transfer of infectious diseases. The present study investigated the cognition-enhancing properties of different types of PS in rats. Seventeen-month-old male Fischer 344 rats were treated daily with a dose of 15 mg/kg of PS derived from… Expand
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Since PS affects both central catecholaminergic and cholinergic transmission, which is known to be impaired in old animals, the possibility that the behavioral effects of PS involve brain dopamine and/or acetylcholine systems is discussed. Expand
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The mechanism of PS protective action against stress-induced behavioral and autonomic changes is unknown, but it may involve the brain level as this drug exerts a noteworthy influence on behavior and autonomics functions. Expand
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TLDR
Administration of egg phosphatidylcholine to mice with dementia improves memory and generally increased brain choline and acetylCholine concentrations to or above the levels of the control normal mice. Expand
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