Cognate Site Identifier analysis reveals novel binding properties of the Sex Inducer homeodomain proteins of Cryptococcus neoformans.

@article{Stanton2009CognateSI,
  title={Cognate Site Identifier analysis reveals novel binding properties of the Sex Inducer homeodomain proteins of Cryptococcus neoformans.},
  author={Brynne C. Stanton and Steven S. Giles and Emilia K. Kruzel and Christopher L. Warren and Aseem Z Ansari and Christina M. Hull},
  journal={Molecular microbiology},
  year={2009},
  volume={72 6},
  pages={1334-47}
}
Homeodomain proteins function in fungi to specify cell types and control sexual development. In the meningoencephalitis-causing fungal pathogen Cryptococcus neoformans, sexual development leads to the production of spores (suspected infectious particles). Sexual development is controlled by the homeodomain transcription factors Sxi1alpha and Sxi2a, but the mechanism by which they act is unknown. To understand how the Sxi proteins regulate development, we characterized their binding properties… CONTINUE READING

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