Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation.

Abstract

The tumor suppressor protein p53 is a nuclear protein that serves as an important transcription factor. The region responsible for sequence-specific DNA interaction is located in its core domain (p53C). Although full-length p53 binds to DNA as a tetramer, p53C binds as a monomer since it lacks the oligomerization domain. It has been previously demonstrated… (More)
DOI: 10.1021/bi9003028

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