Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses.

@article{Jang2005CofilinEI,
  title={Cofilin expression induces cofilin-actin rod formation and disrupts synaptic structure and function in Aplysia synapses.},
  author={Dong-Hyuk Jang and Jin Hee Han and Seung-Hee Lee and Yong-Seok Lee and Hyungju Park and Sue-Hyun Lee and Hyoung Kook Kim and Bong-Kiun Kaang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 44},
  pages={16072-7}
}
Cofilin-actin rods are inclusion-like structures that are induced by certain chemical or physical stresses in cultured cells, and the rods formed in neurons are thought to be associated with neurodegeneration. Here, we cloned an Aplysia cofilin homolog and overexpressed it in cultured neurons. Overexpressed cofilin formed rod-like structures that included actin. The overall neuronal morphology was unaffected by cofilin overexpression; however, a decrease in number of synaptic varicosities was… CONTINUE READING