Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module

@inproceedings{Wiggan2017CofilinRN,
  title={Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module},
  author={O Wiggan and Bryce W. Schroder and Diego Krapf and James R. Bamburg and Jennifer G DeLuca},
  booktitle={Scientific reports},
  year={2017}
}
Structural features of the nucleus including shape, size and deformability impact its function affecting normal cellular processes such as cell differentiation and pathological conditions such as tumor cell migration. Despite the fact that abnormal nuclear morphology has long been a defining characteristic for diseases such as cancer relatively little is known about the mechanisms that control normal nuclear architecture. Mounting evidence suggests close coupling between F-actin cytoskeletal… CONTINUE READING
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