Cofilin Changes the Twist of F-Actin: Implications for Actin Filament Dynamics and Cellular Function

Abstract

Cofilin is an actin depolymerizing protein found widely distributed in animals and plants. We have used electron cryomicroscopy and helical reconstruction to identify its binding site on actin filaments. Cofilin binds filamentous (F)-actin cooperatively by bridging two longitudinally associated actin subunits. The binding site is centered axially at… (More)

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@article{McGough1997CofilinCT, title={Cofilin Changes the Twist of F-Actin: Implications for Actin Filament Dynamics and Cellular Function }, author={Amy M McGough and Brian J Pope and Wah Chiu and Alan G Weeds}, journal={The Journal of Cell Biology}, year={1997}, volume={138}, pages={771 - 781} }