Coffee contains potent opiate receptor binding activity

@article{Boublik1983CoffeeCP,
  title={Coffee contains potent opiate receptor binding activity},
  author={Jaroslav H. Boublik and Michael J. Quinn and John C. Clements and Adrian C. Herington and Kamil Wynne and John W. Funder},
  journal={Nature},
  year={1983},
  volume={301},
  pages={246-248}
}
Opiate receptor-active peptide fragments (exorphins) have been identified recently in casein1 and gluten2 hydrolysates, and morphine has been found in bovine and human milk3. To determine whether similar peptides or alkaloids occur in other foodstuffs, we have screened potential sources using a rat brain homogenate assay to detect opiate receptor activity. We report here that instant coffee powders from a variety of manufacturers compete with tiitiated naloxone for binding to opiate receptors… CONTINUE READING
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