Coffee consumption and risk of hypertension: a systematic review and dose–response meta-analysis of cohort studies

  title={Coffee consumption and risk of hypertension: a systematic review and dose–response meta-analysis of cohort studies},
  author={Chen Xie and Lingling Cui and Jicun Zhu and Kehui Wang and Nan Sun and Changqing Sun},
  journal={Journal of Human Hypertension},
Some debates exist regarding the association of coffee consumption with hypertension risk. We performed a meta-analysis including dose–response analysis aimed to derive a more quantitatively precise estimation of this association. PubMed and Embase were searched for cohort studies published up to 18 July 2017. Fixed-effects generalized least-squares regression models were used to assess the quantitative association between coffee consumption and hypertension risk across studies. Restricted… 
Coffee and caffeine consumption in women affected by hypertension
It is concluded that in the population of women living in the Mediterranean Area, the intake of coffee and caffeine do not increase significantly blood pressure and the main confounder is the presence of the healthy “Mediterranean” diet.
Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Hypertension
High-density lipoprotein cholesterol, triglycerides, body mass index, alcohol dependence, insomnia, and educational level were identified as causal risk factors for hypertension, implicates that these modifiable risk factors are important targets in the prevention of hypertension.
Caffeine and blood pressure: a critical review perspective
All methodological aspects and confounding factors are considered to generate a standardised methodology in order to increase cross-study consistency and minimise confounding effects of different variables on the relationship between BP response and HPT risk/incidence after caffeine intake.
The Relationship between Habitual Coffee Drinking and the Prevalence of Metabolic Syndrome in Taiwanese Adults: Evidence from the Taiwan Biobank Database
The study results indicate that adults with habitual coffee drinking behaviors of more than one cup per day were associated with a lower prevalence of MetS, and women could benefit from habitual coffee Drinking of all three coffee types, whereas men could only benefit from drinking BC.
Is knee osteoarthritis related to coffee drinking? A nationwide cross-sectional observational study
Daily more than 7 cups of coffee drinking was associated with a prevalence of knee OA in Korean men, and although the ORs did not increase significantly across consumption levels, the prevalence of knees OA tended to increase with increasing coffee consumption.
Caffeine and caffeine metabolites in relation to hypertension in U.S. adults
  • G. Ngueta
  • Medicine
    European Journal of Clinical Nutrition
  • 2019
Final metabolites of caffeine, but not caffeine, significantly reduce the odds for hypertension in this population of adults, with 7-MU being the more powerful metabolite.
Metabolic Disorders in Patients with Chronic Hepatitis B Virus Infection: Coffee as a Panacea? (ANRS CO22 Hepather Cohort)
Elevated coffee consumption was associated with a higher risk of dyslipidemia and a lower risk of hypertension in HBV-infected patients, two effects expected to be associated with favorable clinical outcomes.
Coffee and Arterial Hypertension
The results of numerous studies and meta-analyses indicate that moderate and habitual coffee consumption does not increase and may even reduce the risk of developing arterial hypertension, and occasional coffee consumption has hypertensinogenic effects.


Habitual coffee consumption and risk of hypertension: a systematic review and meta-analysis of prospective observational studies.
The results suggest that habitual coffee consumption of >3 cups/d was not associated with an increased risk of hypertension compared with <1 cup/d; however, a slightly elevated risk appeared to be associated with light-to-moderate consumption of 1 to 3 Cups/d.
Caffeinated and Decaffeinated Coffee Consumption and Risk of Type 2 Diabetes: A Systematic Review and a Dose-Response Meta-analysis
Coffee consumption was inversely associated with the risk of type 2 diabetes in a dose-response manner and both caffeinated and decaffeinated coffee was associated with reduced diabetes risk.
Coffee consumption and risk of hypertension in the Polish arm of the HAPIEE cohort study
Relation between coffee consumption and incidence of hypertension was related to smoking status and consumption of 3–4 cups of coffee per day decreased the risk of hypertension in non-smoking men and women only.
The effect of coffee consumption on blood pressure and the development of hypertension: a systematic review and meta-analysis
Low-quality evidence did not show any statistically significant effect of coffee consumption on BP or the risk of hypertension, and no recommendation can be made for or against coffee consumption as it relates to BP and hypertension.
Association between coffee consumption and risk of hypertension
In subjects screened for stage 1 hypertension a nonlinear association was found between coffee consumption and development of sustained hypertension.
CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension
It is shown that the risk of hypertension associated with coffee intake varies according to CYP1A2 genotype, and carriers of slow *1F allele are at increased risk and should thus abstain from coffee, whereas individuals with *1A/*1A genotype can safely drink coffee.
Coffee intake and incidence of hypertension.
Coffee abstinence is associated with a lower hypertension risk than is low coffee consumption, and an inverse U-shaped relation between coffee intake and risk of hypertension was observed in the women.
Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials
Regular caffeine intake increases blood pressure, however, the blood pressure effect of caffeine is small when ingested through coffee.
Habitual coffee consumption and blood pressure: An epidemiological perspective
Although the precise nature of the relation between coffee and BP is still unclear, most evidence suggests that regular intake of caffeinated coffee does not increase the risk of hypertension.
Coffee consumption and the incidence of antihypertensive drug treatment in Finnish men and women.
It is indicated that coffee drinking seems to increase the risk of antihypertensive drug treatment, and this risk was higher in subjects with low-to-moderate coffee intakes; however, there was no significantly increased trend in drinkers of approximately 1 cup (100 mL)/d or >or=8 cups/d.