Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study.

@article{Dik2014CoffeeAT,
  title={Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk-results from the EPIC cohort study.},
  author={Vincent K. Dik and H. B. Bueno-de-Mesquita and Martijn G. H. van Oijen and Peter D. Siersema and Cuno S. P. M. Uiterwaal and Carla H van Gils and Fr{\"a}nzel J. B. van Duijnhoven and St{\'e}phane Cauchi and Loic Yengo and Philippe Froguel and Kim Overvad and Bodil Hammer Bech and Anne Tj\onneland and Anja Olsen and Marie-Christine Boutron-Ruault and Antoine Racine and Guy Fagherazzi and Tilman K{\"u}hn and Daniele Campa and H. B{\"o}ing and Krasimira Aleksandrova and Antonia Trichopoulou and Eleni Peppa and Eleni Oikonomou and Domenico Palli and Sara Grioni and Paolo Vineis and Rosaria Tumino and Salvatore Panico and P. H. Peeters and Elisabete Weiderpass and Dagrun Engeset and Tonje Braaten and Miren Dorronsoro and M D Chirlaque and M P{\'e}rez S{\'a}nchez and Aurelio Barricarte and Raul Zamora-Ros and Marcial Vicente Arg{\"u}elles and Karin Jirstr{\"o}m and Peter Wallstr{\"o}m and Lena M Nilsson and Ingrid Ljuslinder and Ruth C. Travis and Kay-Tee Khaw and Nicholas J Wareham and Heinz Freisling and Idlir Licaj and M. Jenab and Marc J. Gunter and Neil Murphy and Dora Romaguera-Bosch and Elio Riboli},
  journal={International journal of cancer},
  year={2014},
  volume={135 2},
  pages={401-12}
}
Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer (CRC). We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes, enzymes involved in the metabolization of caffeine. Data from 477,071 participants (70.2% female) of the European Investigation into Cancer and Nutrition (EPIC) cohort study were analyzed. At… CONTINUE READING

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CaffeineNo subtypeCoffee
We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes , enzymes involved in the metabolization of caffeine .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
CaffeineNo subtypeTea
Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer ( CRC ) .
We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes , enzymes involved in the metabolization of caffeine .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
CaffeineNo subtypeTea
Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer ( CRC ) .
We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes , enzymes involved in the metabolization of caffeine .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
TeaNo subtypeCaffeine
We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes , enzymes involved in the metabolization of caffeine .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer ( CRC ) .
CoffeeNo subtypeCaffeine
We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes , enzymes involved in the metabolization of caffeine .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
CoffeeNo subtypeTea
Total coffee consumption ( high vs. non / low ) was not associated with CRC risk ( HR 1.06 , 95% CI 0.95 - 1.18 ) or subsite cancers , and no significant associations were found for caffeinated ( HR 1.10 , 95% CI 0.97 - 1.26 ) and decaffeinated coffee ( HR 0.96 , 95% CI 0.84 - 1.11 ) and tea ( HR 0.97 , 95% CI 0.86 - 1.09 ) .
We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes , enzymes involved in the metabolization of caffeine .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
This study shows that coffee and tea consumption is not likely to be associated with overall CRC .
At baseline ( 1992 - 2000 ) habitual ( total , caffeinated and decaffeinated ) coffee and tea consumption was assessed with dietary questionnaires .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
Total coffee consumption ( high vs. non / low ) was not associated with CRC risk ( HR 1.06 , 95% CI 0.95 - 1.18 ) or subsite cancers , and no significant associations were found for caffeinated ( HR 1.10 , 95% CI 0.97 - 1.26 ) and decaffeinated coffee ( HR 0.96 , 95% CI 0.84 - 1.11 ) and tea ( HR 0.97 , 95% CI 0.86 - 1.09 ) .
TeaNo subtypeCoffee
Total coffee consumption ( high vs. non / low ) was not associated with CRC risk ( HR 1.06 , 95% CI 0.95 - 1.18 ) or subsite cancers , and no significant associations were found for caffeinated ( HR 1.10 , 95% CI 0.97 - 1.26 ) and decaffeinated coffee ( HR 0.96 , 95% CI 0.84 - 1.11 ) and tea ( HR 0.97 , 95% CI 0.86 - 1.09 ) .
Total coffee consumption ( high vs. non / low ) was not associated with CRC risk ( HR 1.06 , 95% CI 0.95 - 1.18 ) or subsite cancers , and no significant associations were found for caffeinated ( HR 1.10 , 95% CI 0.97 - 1.26 ) and decaffeinated coffee ( HR 0.96 , 95% CI 0.84 - 1.11 ) and tea ( HR 0.97 , 95% CI 0.86 - 1.09 ) .
We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes , enzymes involved in the metabolization of caffeine .
At baseline ( 1992 - 2000 ) habitual ( total , caffeinated and decaffeinated ) coffee and tea consumption was assessed with dietary questionnaires .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
This study shows that coffee and tea consumption is not likely to be associated with overall CRC .
TeaNo subtypeCaffeine
We investigated the association between coffee and tea consumption and CRC risk and studied potential effect modification by CYP1A2 and NAT2 genotypes , enzymes involved in the metabolization of caffeine .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
High coffee and tea consuming subjects with slow CYP1A2 or NAT2 activity had a similar CRC risk compared to non / low coffee and tea consuming subjects with a fast CYP1A2 or NAT2 activity , which suggests that caffeine metabolism does not affect the link between coffee and tea consumption and CRC risk .
Coffee and tea contain numerous antimutagenic and antioxidant components and high levels of caffeine that may protect against colorectal cancer ( CRC ) .
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