Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: A systematic review

  title={Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: A systematic review},
  author={Francesco Panza and Vincenzo Solfrizzi and M. R. Barulli and Caterina Bonfiglio and Vito Guerra and Alberto Rub{\'e}n Osella and Davide Seripa and Carlo Sabb{\`a} and Alberto Pilotto and Giancarlo Logroscino},
  journal={The journal of nutrition, health \& aging},
A prolonged preclinical phase of more than two decades before the onset of dementia suggested that initial brain changes of Alzheimer’s disease (AD) and the symptoms of advanced AD may represent a unique continuum. Given the very limited therapeutic value of drugs currently used in the treatment of AD and dementia, preventing or postponing the onset of AD and delaying or slowing its progression are becoming mandatory. Among possible reversible risk factors of dementia and AD, vascular… 

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

The reports of studies on experimental AD models generally supported the notion that caffeine may exert some beneficial effects in AD, however, further studies are necessary to elucidate the role of caffeine in the effects of its sources on cognition and possibly AD risk.

The Effects of Coffee Consumption on Cognition and Dementia Diseases

There is now considerable knowledge obtained from epidemiological evidence and animal studies, that 3 to 5 cups of caffeine-coffee improves-corrects, positively changes the trajectory of age-related neurodegenerative decline, supporting the healthy aging effects of coffee consumption for dementia prevention and AD.

Neuroprotective Effect of Caffeine in Alzheimer’s Disease

There is robust evidence based on in vivo and in vitro studies that caffeine has neuroprotective properties in AD animal models, but further studies are needed to identify the mechanistic pathways mediating these effects.

Prospective Associations between Single Foods, Alzheimer’s Dementia and Memory Decline in the Elderly

No evidence for these single foods to be protective against cognitive decline is found, with the exception of red wine, which reduced the risk for AD only in men.

Associations of Green Tea Consumption and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Pathology in Cognitively Intact Older Adults: The CABLE Study.

The favorable effects of green tea on the mitigation of AD risk are consolidated and the constituents of greenTea may improve abnormal tau metabolism and are promising targets in interventions and drug therapies.

Dietary Patterns and Cognitive Decline: key features for prevention.

The evidence for the effects of some dietary patterns as neuroprotective, with potential to delay cognitive decline and the onset of dementia are examined.

Relationships of Dietary Patterns, Foods, and Micro- and Macronutrients with Alzheimer's Disease and Late-Life Cognitive Disorders: A Systematic Review.

In the last decade, the association between diet and cognitive function or dementia has been largely investigated. In the present article, we systematically reviewed observational studies published

Drinking coffee may reduce chances of developing Alzheimer’s disease: systematic literature review and meta-analysis

A systematic literature review and quantitative synthesis meta-analysis that included dose-response analysis on the relationship between the consumption of coffee and the risk of developing Alzheimer’s disease and showed that there is low heterogeneity between the studies.

Lifestyle-related factors in predementia and dementia syndromes

Results are awaited from large multicenter randomized clinical trials in older persons that may clarify the possible synergy, for example, between moderate exercise, physical activity and healthy Mediterranean diet on cognition in the elderly.

Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study.

Caffeine drinkers at midlife had lower risk of dementia and AD later in life compared with those drinking no or only little coffee adjusted for demographic, lifestyle and vascular factors, apolipoprotein E epsilon4 allele and depressive symptoms.

Diet and Alzheimer’s disease risk factors or prevention: the current evidence

Findings suggested that adherence to the MeDi may affect not only the risk of AD, but also of predementia syndromes and their progression to overt dementia.

Effectiveness of the Mediterranean diet: can it help delay or prevent Alzheimer's disease?

A recent meta-analysis from this group, comprising prospective studies that investigated the association between adherence to Mediterranean diet and health status, showed a significant association between a greater adherence toiterranean diet and a reduced risk of major chronic degenerative diseases, including AD.

Mediterranean diet and cognitive decline

Essential components of the Mediterranean diet – MUFA, cereals and wine – seem to be protective against cognitive decline, and dietary antioxidants and supplements, specific macronutrients ofThe Mediterranean diet, oestrogens and anti-inflammatory drugs may act synergistically with other protective factors, opening up new therapeutic interventions for cognitive decline.

The role of diet in cognitive decline

In an older population of Southern Italy with a typical Mediterranean diet, high monounsaturated fatty acids energy intake appeared to be associated with a high protection against cognitive decline, and dietary fat and energy in older people seem to be risk factors.

Does caffeine intake protect from Alzheimer's disease?

Caffeine intake was associated with a significantly lower risk for AD, independently of other possible confounding variables, and may have a major impact on the prevention of AD.

Coffee intake in midlife and risk of dementia and its neuropathologic correlates.

Coffee and caffeine intake in midlife were not associated with cognitive impairment, dementia, or individual neuropathologic lesions, although higher caffeine intake was associated with a lower odds of having any of the lesion types at autopsy.

Caffeine, diabetes, cognition, and dementia.

  • G. Biessels
  • Medicine
    Journal of Alzheimer's disease : JAD
  • 2010
Recommendations for coffee consumption in individuals with T2DM or pre-diabetic stages are difficult to establish, but it should be acknowledged that caffeine does appear to have several properties that warrant further investigations in this field.

Caffeine intake is associated with a lower risk of cognitive decline: a cohort study from Portugal.

It is confirmed that the negative association between caffeine and cognitive decline in women is confirmed, in a cohort of adults living in Porto.