Coffea arabica extract and its constituents prevent photoaging by suppressing MMPs expression and MAP kinase pathway.

@article{Chiang2011CoffeaAE,
  title={Coffea arabica extract and its constituents prevent photoaging by suppressing MMPs expression and MAP kinase pathway.},
  author={Hsiu-Mei Chiang and Tse-min Lin and Chen-Yuan Chiu and Chiung-wen Chang and Kuo-Chiu Hsu and Peng Fan and Kuo-Ching Wen},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2011},
  volume={49 1},
  pages={
          309-18
        }
}
UV is a potent factor in skin photoaging and photocarcinogenesis. Therefore, investigating the inhibiting mechanisms of photoaging would be useful to enable development of agents to slow down the aging process. UV-irradiation increased metalloproteinase (MMP)-1, -3, and -9 and then causes collagen and elastin degradation, leading to the formation of coarse wrinkles and sagging skin. Polyphenols, a group of compounds, possessing a variety of biological activities including inhibition of MMP-1… CONTINUE READING
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