Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions.

@article{Deleault2012CofactorMM,
  title={Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions.},
  author={Nathan R. Deleault and Daniel J. Walsh and Justin R. Piro and Fei Wang and Xinhe Wang and Jiyan Ma and Judy R Rees and Surachai Supattapone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 28},
  pages={E1938-46}
}
Prions containing misfolded prion protein (PrP(Sc)) can be formed with cofactor molecules using the technique of serial protein misfolding cyclic amplification. However, it remains unknown whether cofactors materially participate in maintaining prion conformation and infectious properties. Here we show that withdrawal of cofactor molecules during serial propagation of purified recombinant prions caused adaptation of PrP(Sc) structure accompanied by a reduction in specific infectivity of >10(5… CONTINUE READING

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