Cofactor interactions and the regulation of glutamate decarboxylase activity

Abstract

More than 50% of glutamate decarboxylase (GAD) in brain is present as apoenzyme. Recent work has opened the possibility that apoGAD can be studied in brain by labeling with radioactive cofactor. Such studies would be aided by a compound that inhibits specific binding. One possibility is 4-deoxy-pyridoxine 5′-phosphate, a close structural analog of the… (More)
DOI: 10.1007/BF00966087

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