Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

@article{Shang2000CofactorDA,
  title={Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription},
  author={Y. Shang and Xiao Hu and J. Direnzo and M. Lazar and Myles Brown},
  journal={Cell},
  year={2000},
  volume={103},
  pages={843-852}
}
Many cofactors bind the hormone-activated estrogen receptor (ER), yet the specific regulators of endogenous ER-mediated gene transcription are unknown. Using chromatin immunoprecipitation (ChIP), we find that ER and a number of coactivators rapidly associate with estrogen responsive promoters following estrogen treatment in a cyclic fashion that is not predicted by current models of hormone activation. Cycles of ER complex assembly are followed by transcription. In contrast, the anti-estrogen… Expand
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