Coexpression of the type 1 growth factor receptor family members HER-1, HER-2, and HER-3 has a synergistic negative prognostic effect on breast carcinoma survival.

@article{Wiseman2005CoexpressionOT,
  title={Coexpression of the type 1 growth factor receptor family members HER-1, HER-2, and HER-3 has a synergistic negative prognostic effect on breast carcinoma survival.},
  author={Sam Wiseman and Nikita Makretsov and Torsten O. Nielsen and Blake C. Gilks and Erika Yorida and Maggie Chon U. Cheang and Dmitry A. Turbin and Karen A. Gelmon and David G. Huntsman},
  journal={Cancer},
  year={2005},
  volume={103 9},
  pages={1770-7}
}
BACKGROUND The clinical significance of coexpression of type 1 growth factor receptor (T1GFR) family members remains largely unknown. The objective of the current study was to determine the frequency and the possible prognostic effect of coexpression of HER-1, HER-2, HER-3, and HER-4 by breast carcinoma. METHODS Tissue microarrays were constructed using clinically annotated formalin-fixed, paraffin-embedded tumor samples from 242 patients with invasive breast carcinomas with a median 15-year… CONTINUE READING