Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth.

@article{Goustin1985CoexpressionOT,
  title={Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth.},
  author={Anton-Scott Goustin and Christer Betsholtz and Susan Pfeifer-Ohlsson and H{\aa}kan Persson and J Rydnert and M. J. Bywater and Gosta Holmgren and Carl-Henrik Heldin and Bengt Westermark and Rolf Ohlsson},
  journal={Cell},
  year={1985},
  volume={41 1},
  pages={301-12}
}
First trimester human placentas actively express the sis proto-oncogene, the structural gene for the B chain of platelet-derived growth factor (PDGF). Using the in situ hybridization technique, the 4.2 kb c-sis transcript has been localized to the cytotrophoblastic component, especially the highly proliferative and invasive cytotrophoblastic shell, paralleling the distribution of c-myc transcripts in early placenta. Explants of first trimester placenta release significant levels of PDGF-like… CONTINUE READING
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