Coexpression of normally incompatible developmental pathways in retinoblastoma genesis.

  title={Coexpression of normally incompatible developmental pathways in retinoblastoma genesis.},
  author={Justina D. McEvoy and Jacqueline Flores-Otero and Jiakun Zhang and Katie M Nemeth and Rachel Brennan and Cori L. Bradley and Fred Krafcik and Carlos Rodriguez-Galindo and Matthew K. Wilson and Shunbin Xiong and Guillermina Lozano and Julien Sage and Ligia C Fu and Lotfi Louhibi and Jeff Trimarchi and Amar K. Pani and Richard J Smeyne and Dianna Johnson and Michael A. Dyer},
  journal={Cancer cell},
  volume={20 2},
It is widely believed that the molecular and cellular features of a tumor reflect its cell of origin and can thus provide clues about treatment targets. The retinoblastoma cell of origin has been debated for over a century. Here, we report that human and mouse retinoblastomas have molecular, cellular, and neurochemical features of multiple cell classes, principally amacrine/horizontal interneurons, retinal progenitor cells, and photoreceptors. Importantly, single-cell gene expression array… CONTINUE READING
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