Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy

@inproceedings{ElAsrar2016CoexpressionOH,
  title={Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy},
  author={Ahmed M Abu El-Asrar and Mohammad Mairaj Siddiquei and Mohd Imtiaz Nawaz and Gert de Hertogh and Ghulam Mohammad and Kaiser Alam and Ahmed Mousa and Ghislain Opdenakker},
  booktitle={Molecular vision},
  year={2016}
}
PURPOSE Heparanase cleaves heparan sulfate side chains of heparan sulfate proteoglycans, activity that is implicated in angiogenesis. Proteolytic cleavage of proheparanase by cathepsin L leads to the formation of catalytically active heparanase. We investigated the expression levels of heparanase enzymatic activity and correlated these with the levels of cathepsin L, the angiogenic factors tissue factor (TF) and matrix metalloproteinase-9 (MMP-9), and the angiostatic factor tissue factor… CONTINUE READING

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