Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma.

Abstract

Von Hippel-Lindau (VHL) disease is characterized by multiple tumors in specific target organs. The tumors at different sites share distinct morphologic and genetic characteristics but their cell of origin is unknown. We show that VHL disease-associated renal clear cell carcinomas (RCC) consistently coexpress erythropoietin (Epo) and Epo receptor (EpoR). In… (More)

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@article{Lee2005CoexpressionOE, title={Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma.}, author={Youn-Soo Lee and Alexander O. Vortmeyer and Irina A. Lubensky and Timothy W A Vogel and Barbara L. Ikejiri and Sophie Ferlicot and G{\'e}rard Beno{\^i}t and Sophie Giraud and Edward H. Oldfield and W. Marston Linehan and Bin Tean Teh and St{\'e}phane Richard and Zhengping Zhuang}, journal={Clinical cancer research : an official journal of the American Association for Cancer Research}, year={2005}, volume={11 3}, pages={1059-64} }