Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness.

@article{Yamanaka1993CoexpressionOE,
  title={Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness.},
  author={Yasutsugu Yamanaka and Helmut Friess and Michael S. Kobrin and Markus W. Bũchler and Hans G{\"u}nther Beger and Murray Korc},
  journal={Anticancer research},
  year={1993},
  volume={13 3},
  pages={565-9}
}
Immunohistochemical analysis for the epidermal growth factor receptor (EGFR), EGF and transforming growth factor-alpha (TGF-alpha) was performed in 87 human pancreatic carcinomas. Expression frequencies for EGFR, EGF, and TGF-alpha were 43%, 46% and 54%, respectively. Coexpression of the receptor and at least one of its ligands occurred in 38% of the tumors, and correlated with large tumor size, advanced clinical staging, and decreased survival period. In situ hybridization revealed that the… CONTINUE READING

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