Coexpression of corticotropin-releasing hormone and urotensin i precursor genes in the caudal neurosecretory system of the euryhaline flounder (Platichthys flesus): a possible shared role in peripheral regulation.

@article{Lu2004CoexpressionOC,
  title={Coexpression of corticotropin-releasing hormone and urotensin i precursor genes in the caudal neurosecretory system of the euryhaline flounder (Platichthys flesus): a possible shared role in peripheral regulation.},
  author={Weiqun Lu and Louise Dow and Sarah Gumusgoz and Matthew J Brierley and Justin M. Warne and Catherine R. McCrohan and Richard John Balment and Daniela Riccardi},
  journal={Endocrinology},
  year={2004},
  volume={145 12},
  pages={5786-97}
}
CRH and urotensin I (UI) are neuroendocrine peptides that belong to the superfamily of corticotropin-releasing factors. In mammals, these peptides regulate the stress response and other central nervous system functions, whereas in fish an involvement for UI in osmoregulation has also been suggested. We have identified, characterized, and localized the genes encoding these peptides in a unique fish neuroendocrine organ, the caudal neurosecretory system (CNSS). The CRH and UI precursors, isolated… CONTINUE READING

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