Coexpression of a mutant β-actin and the two normal β- and γ-cytoplasmic actins in a stably transformed human cell line

@article{Vandekerckhove1980CoexpressionOA,
  title={Coexpression of a mutant $\beta$-actin and the two normal $\beta$- and $\gamma$-cytoplasmic actins in a stably transformed human cell line},
  author={Joël Vandekerckhove and John Leavitt and Takeo Kakunaga and Klaus Weber},
  journal={Cell},
  year={1980},
  volume={22},
  pages={893-899}
}
Abstract HUT 14 is a cloned transformed cell line derived from normal diploid human KD fibroblasts. HUT 14 cells have an altered actin phenotype. In addition to the two nonmuscle actins β and γ, also present in the parent KD cells, they show the stable expression of a novel actin species (A x -actin). Amino acid sequence analysis has been used to identify the three actins of HUT 14 cells. β- and γ-actins are identified as normal mammalian nonmuscle actins whereas A x -actin is characterized as… Expand
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