Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons

  title={Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons},
  author={C. Lewis and S. Neidhart and C. Holy and R. A. North and G. Buell and A. Surprenant},
  • C. Lewis, S. Neidhart, +3 authors A. Surprenant
  • Published 1995
  • Biology, Medicine
  • Nature
  • Cation-selective P2X receptor channels were first described in sensory neurons1-4 where they are important for primary afferent neurotransmission and nociception5,6. Here we report the cloning of a complementary DNA (P2X3) from rat dorsal root ganglia that had properties dissimilar to those of sensory neurons. We also found RNA for (P2X1) (ref. 7), (P2X2) (ref. 8) and P2X4 (ref. 9) in sensory neurons; channels expressed from individual cDNAs did not reproduce those of sensory ganglia… CONTINUE READING
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