Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.

@article{Chiou2010CoexpressionOO,
  title={Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.},
  author={Shih-Hwa Chiou and Mong-Lien Wang and Y T Chou and Chi-Jen Chen and Chun-Fu Hong and Wang-Ju Hsieh and Hsin-Tzu Chang and Ying-Shan Chen and Tzu-Wei Lin and Han-Sui Hsu and C Wu},
  journal={Cancer research},
  year={2010},
  volume={70 24},
  pages={10433-44}
}
Epithelial-mesenchymal transition (EMT), a critical process of cancer invasion and metastasis, is associated with stemness property of cancer cells. Though Oct4 and Nanog are homebox transcription factors essential to the self-renewal of stem cells and are expressed in several cancers, the role of Oct4/Nanog signaling in tumorigenesis is still elusive. Here… CONTINUE READING